On March 4, 2004, Thorarensen, Atli; Ruble, Craig J.; Romero, Donna L. published a patent.Quality Control of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of aminoarylbenzoic acid derivatives as antibacterial agents for use as disinfectants and therapeutic agents. And the patent contained the following:
The title compounds I [X = NH; Y = CO, CS, C=NCN, or X and Y together form an alkene, or cycloalkyl; R1 = CO2H; R2 = electron withdrawing group; R4 = (un)substituted aryl with provisions] and their pharmaceutically acceptable salts are prepared and disclosed as antibacterial agents. Thus, e.g., II was prepared by conversion of 4-(chlorosulfonyl)benzoic acid to the acid chloride then amidated with Me 2-amino-5-bromobenzoate with subsequent reaction with di-Et amine and hydrolysis to give the benzoic acid moiety. In assays, the min. inhibitory concentration values (μg/mL) ranged from 0.125 – >128. As antibacterial agents I are useful for sterilization, sanitation, antisepsis, and disinfection. Claims for therapeutic use of I as an antibacterial agent are made. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Quality Control of 6-Chloro-2,3-dihydro-1H-indole
The Article related to benzoic acid aminoaryl preparation antibacterial agent antisepsis disinfection, aminoarylbenzoic acid preparation antibacterial agent sterilization sanitation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Quality Control of 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles