On November 2, 2016, Tian, Maoqun; Yan, Ming; Baran, Phil S. published an article.SDS of cas: 152213-63-3 The title of the article was 11-Step Total Synthesis of Araiosamines. And the article contained the following:
A concise route to a small family of exotic marine alkaloids known as the araiosamines has been developed, and their absolute configuration has been assigned. The dense array of functionality, high polarity, and rich stereochem. coupled with equilibrating topologies present an unusual challenge for chem. synthesis and an opportunity for innovation. Key steps involve the use of a new reagent for guanidine installation, a remarkably selective C-H functionalization, and a surprisingly simple final step that intersects a presumed biosynthetic intermediate. Synthetic araiosamines were shown to exhibit potency against Gram-pos. and -neg. bacteria despite a contrary report of no activity. The experimental process involved the reaction of Methyl 2-(6-bromo-1H-indol-3-yl)acetate(cas: 152213-63-3).SDS of cas: 152213-63-3
The Article related to araiosamine biomimetic preparation antibacterial gram pos neg, guanidinylation agent araiosamine preparation, carbon hydrogen bond functionalization araiosamine preparation and other aspects.SDS of cas: 152213-63-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles