Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents was written by Tilley, Jefferson W.;LeMahieu, Ronald A.;Carson, Mathew;Kierstead, Richard W.;Baruth, Herman W.;Yaremko, Bohdan. And the article was included in Journal of Medicinal Chemistry in 1980.Product Details of 150560-58-0 This article mentions the following:
Eight title compounds I (R = CO2H, H, Me, or CHMe2; R1 = H, Me, CHMe2, Ac, N(:CMe)OMe, or CO2H) were synthesized by the Ni carbonyl mediated carboxylation of the corresponding bromides. Comparable antiallergy activities were observed for both the 2-alkyl-8-carboxy and the corresponding 8-alkyl-2-carboxy analogs. I; R = CO2H, R1 = CHMe2 [68700-95-8] was one of the most active substances administered orally in the rat passive cutaneous anaphylasis test. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0Product Details of 150560-58-0).
5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 150560-58-0
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Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles