Tong, Kun published the artcileVisible-Light-Induced Direct Oxidative C-H Amidation of Heteroarenes with Sulfonamides, Related Products of indole-building-block, the main research area is heterocyclic compound preparation regioselective photochem; heteroarene sulfonamide oxidative carbon hydrogen amidation iridium catalyst; C−H amidation; heterocycles; nitrogen-centered radicals; photochemistry; visible light.
A direct oxidative C-H amidation of heteroarenes, e.g., I, with sulfonamides RNHSO2R1 [R = CH3, C6H5, oxan-4-yl, etc.; R1 = CH3(CH2)4, C6H5, c-C3H5, pyridin-3-yl, etc.] via nitrogen-centered radicals has been described. Nitrogen-centered radicals are directly generated from oxidative cleavage of NH bonds under visible-light photoredox catalysis. Sulfonamides, which are easily accessed, used as tunable nitrogen sources. Bleach (aqueous NaClO solution), which is clean and economic, was used as the solely oxidant. A variety of heteroarenes, including indoles, pyrroles, and benzofurans, can undergo this amidation with high yields (up to 92%). These reactions are highly regioselective, and all the products, e.g., II, are isolated as single regioisomer.
Chemistry – A European Journal published new progress about Amidation (regioselective). 13523-93-8 belongs to class indole-building-block, name is 4-(Benzyloxy)-1-methyl-1H-indole, and the molecular formula is C16H15NO, Related Products of indole-building-block.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles