Authors Bilginer, S; Bardaweel, SK; Sabbah, DA; Gul, HI in BENTHAM SCIENCE PUBL LTD published article about in [Bilginer, Sinan; Gul, Halise Inci] Ataturk Univ, Fac Pharm, Dept Pharmaceut Chem, TR-25240 Erzurum, Turkey; [Bardaweel, Sanaa K.] Univ Jordan, Sch Pharm, Dept Pharmaceut Sci, Queen Rania St, Amman 11942, Jordan; [Sabbah, Dima A.] Zaytoonah Univ Jordan, Fac Pharm, Dept Pharm, Amman 11733, Jordan in 2021.0, Cited 53.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Background: Cancer is a life-threatening group of diseases and universally, the second main cause of death. The design and development of new scaffolds targeting selective cancer cells are considered a promising goal for cancer treatment. Aims and Objective: Chalcone derivatives; 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolone, were previously prepared and evaluated against the oral cavity squamous cell carcinoma cell line, HSC-2, and were reported to have remarkably high tumor selectivity. The aim of this study was to further investigate the anticancer activities of the chalcone derivatives against human colon cancer cells with a possible elucidation of their mechanism of action. Methods: Computational studies were conducted to explore the potential interaction of the synthesized molecules with the phosphatidylinositol-4,5-bisphosphate 3-kinasea (PI3K alpha). Biological evaluation of the antiproliferative activities associated with compounds 1-23 was carried out against the colon cancer cell line, HCT116. Lactate Dehydrogenase (LDH) activity was measured to study necrosis, while the caspase-3 activation and DNA measurements were used to evaluate apoptosis in the treated cells. Results: Glide studies against PI3K alpha kinase domain demonstrated that the 6-(3-aryl-2-propenoyl)-2(3H)benzoxazolone scaffold forms H-bond with K802, Y836, E849, V851, N853, Q859, and D933, and it fits the fingerprint of PI3K alpha active inhibitors. Biological evaluation of the reported compounds in HCT116 cell line confirmed that the series inhibited PI3K alpha activity and induced apoptosis via activation of caspase-3 and reduction of DNA content. Conclusion: The recently developed compounds might be employed as lead structures for the design of new antitumor drugs targeting PI3K alpha.
Name: 4-Methoxybenzaldehyde. Welcome to talk about 123-11-5, If you have any questions, you can contact Bilginer, S; Bardaweel, SK; Sabbah, DA; Gul, HI or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles