Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 127-69-5, Name is Sulfisoxazole, molecular formula is C11H13N3O3S, belongs to indole-building-block compound. In a document, author is Wang, Xin-Wei, introduce the new discover, Application In Synthesis of Sulfisoxazole.
Chiral phosphoric acid-catalyzed regioselective synthesis of spiro aminals with quaternary stereocenters
A chiral phosphoric acid-catalyzed enantioselective synthesis of spiro[indoline-3,6′-indolo[1,2-c]quinazolin]-2-ones has been developed by condensation/N-alkylation cascade from 2-(1H-indolyl)anilines and isatins, affording the spiro aminals with quaternary stereogenic centers with up to 93% ee. The protocol could be expanded to 2-(3,5-dimethyl-1H-pyrrol-2-yl)aniline and a variety of pyrrole-derived spiro chiral aminals were also obtained in good yields (71-91%) with excellent enantioselectivities (89%-94% ee). (C) 2021 Elsevier Ltd. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles