Synthetic Route of 1918-77-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1918-77-0, Name is 2-(Thiophen-2-yl)acetic acid, SMILES is O=C(O)CC1=CC=CS1, belongs to indole-building-block compound. In a article, author is Cai, Ju, introduce new discover of the category.
Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused indole and Spirooxindole Derivatives
An unprecedented gold-catalyzed bicyclization reaction of diaryl alkynes has been developed for the synthesis of indoles in good to high yields. Mechanistically, this alkyne bifunctionalization transformation was terminated by a stepwise formal X-H insertion reaction to furnish the corresponding polycyclic-frameworks with structural diversity, and the key intermediate 3H-indole was isolated and characterized for the first time. In addition, further transformation of these generated tetracyclic-indoles with PCC as the oxidant provided straightforward access to the spirooxindoles in high yields.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles