Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Tamilarasan, B., once mentioned the application of 99-96-7, Name is 4-Hydroxybenzoic acid, molecular formula is C7H6O3, molecular weight is 138.1207, MDL number is MFCD00002547, category is indole-building-block. Now introduce a scientific discovery about this category, Recommanded Product: 4-Hydroxybenzoic acid.
An efficient route for the synthesis and study of biological activity of eight membered indole fused compounds has been found by employing methyl-benzaldehyde to condense with a precursor cycloocta[b]indole derivative to give condensed product namely, 2-(4′-methyl-benzylidene)-1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 3. Using 3, further compounds have been prepared namely, pyrazolinocycloocta[b]indole and isoxazolocycloocta[b]indole derivatives by allowing the condensed product to react with hydrazine hydrate and hydroxylamine hydrochloride, which results in the formation of 3-(4′-methyl-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolino[4′,5′:7,8]cycloocta[b]indoles 4 and 3-(4′-methyl-phenyl)-4,5,6,7-tetrahydroisoxazolo[4′,3′:7,8]cycloocta[b]indoles 5. Their biological activities have been studied against bacterial and fungal strains.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles