Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 50332-66-6, Name is 3-Nitroquinolin-4-ol, molecular formula is C9H6N2O3, belongs to indole-building-block compound. In a document, author is Stevens, Michael A., introduce the new discover, Application In Synthesis of 3-Nitroquinolin-4-ol.
Atom Efficient Magnesiation of N-Substituted Alkyl Indoles with a Mixed Sodium-Magnesium Base
This study presents the alkali metal mediated magnesiation (AMMMg) of three N-alkylated indoles with the mixed Na/Mg base [(TMEDA)Na(TMP)(2)Mg(CH2SiMe3)] 1 (TMEDA = N,N,N ‘,N ‘-tetramethylethylenediamine, TMP = 2,2,6,6-tetramethylpiperidine). All three magnesiated indoles have been successfully characterised by single-crystal X-ray diffraction and solution state NMR studies, whereas iodolysis and Pd-catalysed cross coupling have been investigated. The steric nature of the N-alkyl group changes the reactivity and efficiency of 1 to give either atom efficient disodium tetraindol-2-ylmagnesiates [(Na-TMEDA)(2)Mg(alpha-C9H8N)(4)] 2 and [(Na-TMEDA)(2)Mg(alpha-C10H11N)(4)] 3, or [(TMEDA)Na(TMP)(-C11H12N)Mg(TMP)] 4, whereby only one indole molecule is selectively deprotonated.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 50332-66-6. Application In Synthesis of 3-Nitroquinolin-4-ol.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles