Reference of 7554-65-6, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7554-65-6, Name is 4-Methyl-1H-pyrazole, SMILES is C1=N[NH]C=C1C, belongs to indole-building-block compound. In a article, author is Ding, Xiang-Feng, introduce new discover of the category.
An organocatalytic asymmetric arylmethylation/N-hemiacetalization of 2-indolyl methane derivatives and 2-enals was developed. Notably, the 2-methyl of indole was readily deprotonated to produce highly reactive nucleophilic species by introducing the nitro group at the C3 position of the indole ring. A spectrum of valuable chiral dihydropyrido[1,2-a]indoles were efficiently constructed with excellent enantioselectivity (up to >99% ee). Furthermore, the corresponding products could be easily functionalized via simple deprotonation and treatment with other electrophiles with excellent diastereoselectivities (>20:1 dr).
Reference of 7554-65-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 7554-65-6 is helpful to your research.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles