Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 51-61-6, Name is 4-(2-Aminoethyl)benzene-1,2-diol, molecular formula is C8H11NO2, belongs to indole-building-block compound. In a document, author is Wang, Da-Qian, introduce the new discover, COA of Formula: C8H11NO2.
Efficient Synthesis of Fused and Bridged Cyclic Pyrrolo[3,4-a]carbazoles via NH4I Promoted Three-component Reaction
NH4I promoted three-component reaction of indoles, cyclic ketones and maleimides in toluene at 140 degrees C afforded polysubstituted cyclic fused pyrrolo[3,4-a]carbazoles in good yields. The reaction mechanism included sequential Lewis acid catalyzed 3-alkenylation of indole, Diels-Alder reaction and aromatization process. More importantly, the similar NH4I promoted reaction of indoles and acetophenones with two molecules of maleimides in refluxing toluene resulted in the complex tetrahydro-4,10a-[3,4]epipyrrolopyrrolo[3,4-a]carbazoles in satisfactory yields via double Diels-Alder reaction. On the other hand, tetrahydropyrrolo[3,4-a]carbazoles can be easily prepared in high yields by conc. HCl catalyzed three-component reaction of indole and acetophenone and one molecules of maleimide in refluxing ethanol.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 51-61-6. COA of Formula: C8H11NO2.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles