In an article, author is Chizhova, Maria, once mentioned the application of 69-78-3, Application In Synthesis of DTNB, Name is DTNB, molecular formula is C14H8N2O8S2, molecular weight is 396.35, MDL number is MFCD00007140, category is indole-building-block. Now introduce a scientific discovery about this category.
Acetic anhydride to the rescue: Facile access to privileged 1,2,3, 4-tetrahydropyrazino[1,2-a]indole core via the Castagnoli-Cushman reaction
Indole-fused cyclic anhydrides earlier deemed unreactive in the Castagnoli-Cushman reaction with imines have been rendered valid participant in this process. The new reaction format involves the use of respective indole-based dicarboxylic acids and in situ cyclodehydration of the latter by acetic anhydride. This finding validates a fundamentally new approach to synthesizing compounds based on the privileged 1,2,3,4-tetrahydropyrazino[1,2-a]indole core characterized by hitherto undescribed substitution pattern. (C) 2018 Elsevier Ltd. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles