In an article, author is Zhao, Yun-Li, once mentioned the application of 284028-89-3, Computed Properties of C14H11F3N2OS, Name is XAV-939, molecular formula is C14H11F3N2OS, molecular weight is 312.31, MDL number is MFCD16879017, category is indole-building-block. Now introduce a scientific discovery about this category.
Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris
Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment of respiratory infections. [GRAPHICS] .
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles