On November 26, 1990, Torii, Sigeru; Okumoto, Hiroshi; Xu, Long He published an article.Product Details of 65417-22-3 The title of the article was A direct approach to 2-substituted 1,4-dihydro-4-oxoquinoline-3-carboxylates by palladium-catalyzed carbonylative cyclization. And the article contained the following:
Carbonylation of 3-substituted 3-(2-haloarylamino)prop-2-enoates I (R = Me, CH2CO2Me, CO2Me, R1 = R2 = H, R3 = Br, iodo; R = Me, R1 = R2 = F, R3 = Br; R = Me, CH2CO2Me, R1 = F, R2 = Cl, R3 = Br) in the presence of Pd(OAc)2 under 20 kgcm-2 of CO at 120° resulted in heterocyclization to form a variety of 2-substituted 1,4-dihydro-4-oxoquinoline-3-carboxylates II in good yields. Lactones III (R1 = R2 = H; R1 = F, R2 = Cl) were prepared similarly. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Product Details of 65417-22-3
The Article related to cyclocarbonylation haloarylaminopropenoate palladium catalyst, quinolinecarboxylate dihydro oxo, propenoate haloarylamino cyclocarbonylation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Product Details of 65417-22-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles