Trost, Barry M. published the artcileEnantioselective Divergent Synthesis of C19-Oxo Eburnane Alkaloids via Palladium-Catalyzed Asymmetric Allylic Alkylation of an N-Alkyl-α,β-unsaturated Lactam, Application In Synthesis of 167015-84-1, the publication is Journal of the American Chemical Society (2019), 141(12), 4811-4814, database is CAplus and MEDLINE.
The C19-oxo-functionalized eburnane alkaloids display a unique chem. structure and interesting biol. activity. Herein, we report a divergent enantioselective strategy to access these alkaloids by use of a challenging palladium-catalyzed asym. allylic alkylation of N-alkyl-α,β-unsaturated lactam I. 19-(S)-OH-Δ14-Vincamone (II, phutdonginin), (-)-19-OH-eburnamine (III), (+)-19-oxoeburnamine (IV), and (+)-19-OH-eburnamonine (V) have been concisely synthesized for the first time in 11 to 13 steps.
Journal of the American Chemical Society published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C22H18O2, Application In Synthesis of 167015-84-1.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles