A short and efficient synthesis of isoindolin-1-ones was written by Tsuritani, Takayuki;Kii, Satoshi;Akao, Atsushi;Sato, Kimihiko;Nonoyama, Nobuaki;Mase, Toshiaki;Yasuda, Nobuyoshi. And the article was included in Synlett in 2006.Reference of 5388-42-1 This article mentions the following:
A short and efficient synthesis of isoindolin-1-ones is reported. Base-induced cyclization of ortho-(hydroxymethyl)benzamides, which were easily prepared from the corresponding phthalides and amines, led predominantly to N-alkylation in good yield. The reaction proceeded under mild conditions and bromine and nitrile substituents were tolerated. The selectivity is explained by HASB theory. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Reference of 5388-42-1).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Reference of 5388-42-1
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles