Ullah, Hayat et al. published their research in Chemical Papers in 2022 | CAS: 150560-58-0

5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Reference of 150560-58-0

Synthesis, in vitro thymidine phosphorylase activity and molecular docking study of thiadiazole bearing isatin analogs was written by Ullah, Hayat;Liaqat, Anjum;Khan, Qudrat Ullah;Taha, Muhammad;Khan, Fahad;Rahim, Fazal;Uddin, Imad;Rehman, Zia Ur. And the article was included in Chemical Papers in 2022.Reference of 150560-58-0 This article mentions the following:

A series of seventeen analogs I (R = 2-nitrophenyl, 2,4-dichlorophenyl, 2-hydrophenyl, etc.; R1 = H, i-Pr; R2 = H, i-Pr, n-Bu, pentyl) were synthesized and characterized through different spectroscopic techniques such as 1H, 13CNMR, HR-EI-MS and was evaluated for in vitro thymidine phosphorylase inhibition. All compounds showed excellent to good thymidine phosphorylase activity having IC50 value ranging between 4.10 ± 0.20 and 54.60 ±1.40μM when compared with standard drug 7-deazaxanthine (IC50 = 38.68 ± 1.12μM). Among the series, compounds I (R = 2-nitrophenyl, R1 = R2 = H) (IC50 = 8.30 ± 0.30μM), I (R = 2,4-dichlorophenyl, R1 = H, R2 = n-Bu) (IC50 = 6.30 ± 0.10μM), I (R = 2,4-dichlorophenyl, R1 = H, R2 = pentyl) (IC50 = 8.40 ± 0.30μM) and I (R = 2-hydrophenyl, R1 = i-Pr, R2 = H) (IC50 = 4.10 ± 0.20μM) were found more potent. Potent compounds were further subjected to mol. docking study to identify their interactions with the active site of amino acid. Structure activity relationship was done for all analogs mostly based on substitution pattern on Ph and isatin rings. In the experiment, the researchers used many compounds, for example, 5-Isopropylindoline-2,3-dione (cas: 150560-58-0Reference of 150560-58-0).

5-Isopropylindoline-2,3-dione (cas: 150560-58-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Reference of 150560-58-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles