On December 17, 2021, Uredi, Dilipkumar; Burra, Amarender Goud; Watkins, E. Blake published an article.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde The title of the article was Rapid Access to 3-Substituted Pyridines and Carbolines via a Domino, Copper-free, Palladium-Catalyzed Sonogashira Cross-Coupling/6π-Aza Cyclization Sequence. And the article contained the following:
Herein, a one-pot, three-component method for the preparation of 3-substituted pyridines such as I [R = H, Me, Ph, tert-butoxycarbonyl; Ar = Ph, 2-MeC6H4, 3-quinolyl, etc.; R1 = H, 6-Me, 8-Me, 5-MeO], II [R2 = R2 = H; R2R3 = HCCH=CHCH; X = S, O] and carbolines via copper-free, palladium-catalyzed Sonogashira cross-coupling with aryl iodides, followed by 6π-aza cyclization was reported. This arylation cross-coupling/annulation cascade provided easy access to substituted, fused pyridines I, II from readily available substrates in good yields (67-92%) with complete selectivity. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde
The Article related to pyridoindolyl methyl aryl preparation, aryl iodide indole carboxaldehyde propargylamine domino sonogashira coupling aza, cyclization catalyst palladium, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Safety of 1,5-Dimethyl-1H-indole-2-carbaldehyde
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles