Ring opening of (1,3-dioxo-1,3-dihydroisoindol-2-yl)amides with amines was written by Usifoh, C. O.;Okunrobo, L. O.;Sanni, S. B.;Oziegbe, F. E.;Ediagbonya, T.. And the article was included in Journal of Chemical Society of Nigeria in 2007.Application of 3130-75-4 This article mentions the following:
The reaction of phthalic anhydride with 尾-alanine and 纬-aminobutyric acid gave the corresponding N-phthaloyl amino acids, which were treated with thionyl chloride to give the acid chlorides I (n = 2, 3). The acid chlorides I were converted to the corresponding N,N-phthaloyl amino acid amides using isopropylamine and benzylamine. Subsequent ring opening of the amides with isopropylamine and benzylamine afforded the corresponding carboxamides II (R = iPr, Bn) in high yield. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Application of 3130-75-4).
4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application of 3130-75-4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles