In 2019,Green Chemistry included an article by Vaidya, Gargi Nikhil; Fiske, Sneha; Verma, Hansa; Lokhande, Shyam Kumar; Kumar, Dinesh. SDS of cas: 399-52-0. The article was titled 《A micellar catalysis strategy applied to the Pd-catalyzed C-H arylation of indoles in water》. The information in the text is summarized as follows:
A modular and selective C-H arylation of indoles I (R = 5-CN, 5-OCH3, 6-Cl, etc.; R1 = H, Me) following the micellar catalysis approach using the third generation “”designer”” surfactant SPGS-550-M in the presence of 1 mol of [(cinnamyl)PdCl]2 under mild conditions has been described. Thus, access to high value C-3-arylated indoles II [R2 = H, F, MeO, CF3, C(O)Me] and C-2-arylated indoles III (Ar = Ph, 4-fluorophenyl, 2H-1,3-benzodioxol-5-yl) was achieved by fulfilling the “”triple bottom line philosophy”” of green chem. The nature of the phosphine ligand was found to be critical for achieving site-selectivity, DPPF and DPPP being the most effective in promoting the arylation at C3-H and C2-H, resp. The reaction is scalable and offers high chemo- (C vs. N) and regio-selectivity (C-3 vs. C-2) with a wide range of functional group tolerance. The surfactant aqueous solution can be recycled and reused without compromising on product yields. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles