Valin, Nathan; Haybron, David; Groves, Linda; Mower, H. F. published their research in Mutation Research, Genetic Toxicology Testing on December 31 ,1985. The article was titled 《The nitrosation of alcohol-induced metabolites produces mutagenic substances》.Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid The article contains the following contents:
The results of mutagen testing of reaction mixtures of nitrite and representative structures of tetrahydro-β-carbolines, tetrahydroisoquinolines, and tryptophols using Salmonella typimimium strains TA100, TA98, and TA97A are presented. All reaction mixtures were pos. for mutagenicity for ≥1 strains except for the nitrosation mixtures of tetrahydroisoquinoline and 1-methyl-1-methoxycarbonyl-1,2,3,4-tetrahydro-β-carboline-HCl [101372-78-5]. The highest mutagenic activity was observed with strain TA98 with the exception of the reaction mixture of 5-hydroxytryptophol [154-02-9] which was more active with TA100. The results came from multiple reactions, including the reaction of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid)
2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Application In Synthesis of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acidThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles