Regiochemistry of the microwave-assisted reaction between aromatic amines and 伪-bromo ketones to yield substituted 1H-indoles was written by Vara, Yosu;Aldaba, Eneko;Arrieta, Ana;Pizarro, Jose L.;Arriortua, Maria I.;Cossio, Fernando P.. And the article was included in Organic & Biomolecular Chemistry in 2008.Recommanded Product: 776-41-0 This article mentions the following:
The scope and regioselectivity of the Bischler (or Bischler-Moehlau) reaction between aromatic amines and 伪-bromo ketones has been studied by computational and exptl. techniques. It has been found that in many cases the reaction yields are improved under microwave irradiation and working in the absence of solvent. When di- and trisubstituted amines are used as substrates the regioselectivity of the reaction is different to that obtained with primary anilines. The reaction between benzene-1,2-diamine and 伪-bromoacetophenones under the same conditions yields 2-substituted quinoxalines instead of indoles. Finally, when pyridin-2-amines and pyrimidin-2-amines are allowed to react with 伪-bromoacetophenones, imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines are obtained. In the experiment, the researchers used many compounds, for example, Ethyl 1H-indole-3-carboxylate (cas: 776-41-0Recommanded Product: 776-41-0).
Ethyl 1H-indole-3-carboxylate (cas: 776-41-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 776-41-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles