On December 10, 2020, Vu, Cuong M.; Le, Khoa B.; Vo, Uyen N.; Van, Vy D. T.; Nguyen, Anh T.; Phan, Nam T. S.; Le, Nhan T. H.; Nguyen, Tung T. published an article.COA of Formula: C11H11NO2 The title of the article was Recyclable CuFe2O4 for the synthesis of 2,3-disubstituted indoles. And the article contained the following:
A method for the CuFe2O4-catalyzed coupling of 2-iodo- or 2-bromoanilines 2-X-RC6H3NH2 (R = H, 4-trifluoromethoxy, 5-trifluoromethyl, etc.; X = I or Br) and acetylacetone or isosteric 1,3-diketones R1C(O)CH2C(O)R2 (R1 = Me, ethyl; R2 = ethoxy, methoxy) to afford 2,3-disubstituted indoles I (R3 = H, 5-bromo, 6-Me, etc.) has been developed. The superparamagnetic material showed superior activity in comparison to other ferrites or copper-based metal-organic frameworks. Functionalities including ester, cyano, and halogen groups were compatible with the reaction conditions. The CuFe2O4 catalyst was easily recoverable and reusable and offers a convenient pathway to afford synthetically useful heterocycles. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).COA of Formula: C11H11NO2
The Article related to indole preparation, haloaniline diketone heterocyclization copper ferrite nanocatalyst recycling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles