Design and synthesis of a dual linker for solid phase synthesis of oleanolic acid derivatives was written by Wang, Shaorong;Fang, Weishuo. And the article was included in Molecules in 2011.Recommanded Product: 2-(2-(2-Hydroxyethoxy)ethyl)isoindoline-1,3-dione This article mentions the following:
A hydrophilic amino-terminated poly(ethylene glycol)-type dual linker for solid phase synthesis of oleanolic acid derivatives I [R = H, CH2O(CH2)2O(CH2)2NH2] using trityl chloride resin was designed and synthesized for the first time. Model reactions in both liquid and solid phase were performed to show the feasibility of its selective cleavage at two different sites. The biol. assay results indicated that the long and flexible alkyl ether functionality in the linker is less likely to be critical for the binding event. Following the successful solid phase synthesis of model compounds, the potential of this dual linker in reaction monitoring and target identification was deemed worthy of further study. In the experiment, the researchers used many compounds, for example, 2-(2-(2-Hydroxyethoxy)ethyl)isoindoline-1,3-dione (cas: 69676-63-7Recommanded Product: 2-(2-(2-Hydroxyethoxy)ethyl)isoindoline-1,3-dione).
2-(2-(2-Hydroxyethoxy)ethyl)isoindoline-1,3-dione (cas: 69676-63-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 2-(2-(2-Hydroxyethoxy)ethyl)isoindoline-1,3-dione
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles