Investigation towards the reductive amination of levulinic acid by B(C6F5)3/hydrosilane system was written by Wang, Tianlong;Xu, Hai;He, Jianghua;Zhang, Yuetao. And the article was included in Tetrahedron in 2020.Application In Synthesis of 2-Phenylisoindolin-1-one This article mentions the following:
The selective transformation of the renewable biomass resources into the highly value-added platform chems. is essentially important for sustainable chem. Here the authors report a simple and highly efficient strategy for the synthesis of N-heterocyclic compounds from the reductive amination of the bio-derived levulinic acid and a wide range of anilines by metal-free B(C6F5)3/hydrosilane catalyst system. Through adjusting the amounts of hydrosilane, the authors can synthesize a series of pyrrolidones or pyrrolidines, resp. Isotope-labeled NMR experiments were conducted to investigate the possible reaction pathway. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Application In Synthesis of 2-Phenylisoindolin-1-one).
2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Application In Synthesis of 2-Phenylisoindolin-1-one
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles