Study on secondary metabolite of Trachelospermum jasminoides endophyte Myrothecium roridum (IFB-E009) was written by Wang, Wei;Jiang, Rong. And the article was included in Anhui Nongye Kexue in 2012.Synthetic Route of C12H14N2O This article mentions the following:
Eight compounds were isolated and identified from liquid fermentation products of Myrothecium roridum (IFB-E009) in Trachelospermum jasminoides, 1-4 were trichothecenes compounds, 5-6 were amides compounds, 7 was cyclic peptide, and 8 was uracil. As indicated by activity test, compound 1,4 showed activities to the human colon cancer cells SW1116. IC50 were 25.68 and 38.93 μmol/L, while the IC50 of adriamycin was 5.31 μmol. The study would provide theory and practice basis for the development and utilization of endophytes in pharmaceutical plants. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Synthetic Route of C12H14N2O).
N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C12H14N2O
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles