A PKS I gene-based screening approach for the discovery of a new polyketide from Penicillium citrinum Salicorn 46 was written by Wang, Xiaomin;Wang, Hui;Liu, Tianxing;Xin, Zhihong. And the article was included in Applied Microbiology and Biotechnology in 2014.Application of 1016-47-3 This article mentions the following:
Salicorn 46, an endophytic fungus isolated from Salicornia herbacea Torr., was identified as Penicillium citrinum based on its internal transcribed spacer and ribosomal large-subunit DNA sequences using a type I polyketide synthase (PKS I) gene screening approach. A new polyketide, penicitriketo (I), and seven known compounds, including ergone (2), (3尾,5伪,8伪,22E)-5,8-epidioxyergosta-6,9,22-trien-3-ol (3), (3尾,5伪,8伪,22E)-5,8-epidioxyergosta-6,22-dien-3-ol (4), stigmasta-7,22-diene-3尾,5伪,6伪-triol (5), 3尾,5伪-dihydroxy-(22E,24R)-ergosta-7,22-dien-6尾-yl oleate (6), Nb-acetyltryptamine (7), and 2-(1-oxo-2-hydroxyethyl) furan (8), were isolated from the culture of Salicorn 46, and their chem. structures were elucidated by spectroscopic anal. Antioxidant experiments revealed that compound I possessed moderate DPPH radical scavenging activity with an IC50 value of 85.33 卤 1.61 渭M. Antimicrobial assays revealed that compound 2 exhibited broad-spectrum antimicrobial activity against Candida albicans, Clostridium perfringens, Mycobacterium smegmatis, and Mycobacterium phlei with minimal inhibitory concentration (MIC) values of 25.5, 25.5, 18.5, and 51.0 渭M, resp. Compound 3 displayed potent antimicrobial activities against C. perfringens and Micrococcus tetragenus with a MIC value of 23.5 渭M. Compounds 5 and 6 showed high levels of selectivity toward Bacillus subtilis and M. phlei with MIC values of 22.5 and 14.4 渭M, resp. The results of this study highlight the use of PCR-based techniques for the screening of new polyketides from endophytic fungi containing PKS I genes. In the experiment, the researchers used many compounds, for example, N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3Application of 1016-47-3).
N-(2-(1H-Indol-3-yl)ethyl)acetamide (cas: 1016-47-3) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 1016-47-3
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles