Optimization of 2-aminothiazole derivatives as CCR4 antagonists was written by Wang, Xuemei;Xu, Feng;Xu, Qingge;Mahmud, Hossen;Houze, Jonathan;Zhu, Liusheng;Akerman, Michelle;Tonn, George;Tang, Liang;McMaster, Brian E.;Dairaghi, Daniel J.;Schall, Thomas J.;Collins, Tassie L.;Medina, Julio C.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Related Products of 85696-95-3 This article mentions the following:
A series of 2-aminothiazole antagonists of the CCR4 receptor were synthesized and their affinity for the receptor evaluated using a [125I]TARC (CCL17) displacement assay. Optimization of these compounds for potency and pharmacokinetic properties led to potent, orally bioavailable antagonists. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indol-4-amine (cas: 85696-95-3Related Products of 85696-95-3).
1-Methyl-1H-indol-4-amine (cas: 85696-95-3) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Related Products of 85696-95-3
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles