Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O was written by Wang, Yong-Chao;Wang, Jun-Liang;Burgess, Kevin S.;Zhang, Jiang-Wei;Zheng, Qiu-Mei;Pu, Ya-Dan;Yan, Li-Jun;Chen, Xue-Bing. And the article was included in RSC Advances in 2018.Name: 5,6-Difluoroindoline-2,3-dione This article mentions the following:
An efficient, green and sustainable approach for the synthesis of novel polycyclic pyrrolidine-fused spirooxindole compounds such as I [R1 = H, Me; R2 = H, Ph; R3 = H, Me; R4 = H, 5-Me, 6-Cl, etc.] and II [X = CH2, S] was developed. The synthesis included a one-pot, three-component, domino reaction of (E)-3-(2-nitrovinyl)-indoles, isatins and chiral polycyclic α-amino acids under catalyst-free conditions at room temperature in EtOH-H2O. The salient features of this methodol. were eco-friendliness, high yields and the ease of preparation of target compounds I without the involvement of toxic solvents and column chromatog. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindoline-2,3-dione (cas: 774-47-0Name: 5,6-Difluoroindoline-2,3-dione).
5,6-Difluoroindoline-2,3-dione (cas: 774-47-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Name: 5,6-Difluoroindoline-2,3-dione
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles