Wawryszyn, Mirella; Sauter, Paul F.; Nieger, Martin; Koos, Martin R. M.; Koehler, Christine; Luy, Burkhard; Lemke, Edward A.; Braese, Stefan published an article in 2018, the title of the article was Synthesis of Azido-Glycans for Chemical Glyco-modification of Proteins.Computed Properties of 130539-43-4 And the article contains the following content:
Chem. produced, accurately linkable oligosaccharides are of importance for the synthesis of neo-glycoproteins. On the route to high-mannose type N-glycans, we present a convenient synthesis of several glycans bearing an azide moiety at the reducing end. An azido-glycan core structure as valuable precursor was modified into the protected N-glycan pentasaccharide core structure and the possibility of modular attachment of different antenna was demonstrated through synthesis of a pentamannose donor and glycosylation with the core structure. The azido function allows for chem. ligation with modified proteins featuring noncanonical cyclooctyne amino acids, providing access to customized glyco-patterns of glycoproteins, e.g., of antibodies that are of high interest for biopharmaceutical applications. The experimental process involved the reaction of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside(cas: 130539-43-4).Computed Properties of 130539-43-4
The Article related to cyclooctyne amino acid glycosylation glycoprotein oligosaccharide synthesis antibody, azido glycan protein synthesis oligosaccharide glycoprotein glycosylation cyclooctyne and other aspects.Computed Properties of 130539-43-4
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