What about chemistry interests you the most 100-51-6

Name: Benzyl Alcohol. Welcome to talk about 100-51-6, If you have any questions, you can contact Bach, J; Eastwood, P; Gonzalez, J; Gomez, E; Alonso, JA; Fonquerna, S; Lozoya, E; Orellana, A; Maldonado, M; Calaf, E; Alberti, J; Perez, J; Andres, A; Prats, N; Carreno, C; Calama, E; De Alba, J; Calbet, M; Miralpeix, M; Ramis, I or send Email.

Name: Benzyl Alcohol. Recently I am researching about STAT PATHWAY; IMMUNE; INFLAMMATION; DISCOVERY; CP-690550, Saw an article supported by the Almirall S.A.Almirall. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Bach, J; Eastwood, P; Gonzalez, J; Gomez, E; Alonso, JA; Fonquerna, S; Lozoya, E; Orellana, A; Maldonado, M; Calaf, E; Alberti, J; Perez, J; Andres, A; Prats, N; Carreno, C; Calama, E; De Alba, J; Calbet, M; Miralpeix, M; Ramis, I. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

Name: Benzyl Alcohol. Welcome to talk about 100-51-6, If you have any questions, you can contact Bach, J; Eastwood, P; Gonzalez, J; Gomez, E; Alonso, JA; Fonquerna, S; Lozoya, E; Orellana, A; Maldonado, M; Calaf, E; Alberti, J; Perez, J; Andres, A; Prats, N; Carreno, C; Calama, E; De Alba, J; Calbet, M; Miralpeix, M; Ramis, I or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles