Elnagar, MM; Samir, S; Shaker, YM; Abdel-Shafi, AA; Sharmoukh, W; Abdel-Aziz, MS; Abou-El-Sherbini, KS in [Elnagar, Mohamed M.; Sharmoukh, Walid; Abou-El-Sherbini, Khaled S.] Natl Res Ctr, Dept Inorgan Chem, 33 El Bohouth St, Giza 12622, Egypt; [Samir, Safia] Theodor Bilharz Res Inst, Dept Biochem & Mol Biol, Giza, Egypt; [Shaker, Yasser M.] Natl Res Ctr, Div Pharmaceut & Drug Ind, Dept Chem Nat & Microbial Prod, Giza, Egypt; [Abdel-Shafi, Ayman A.] Ain Shams Univ, Fac Sci, Cairo, Egypt; [Abdel-Aziz, Mohamed S.] Natl Res Ctr, Dept Microbial Chem, Giza, Egypt published Synthesis, characterization, and evaluation of biological activities of new 4 ‘-substituted ruthenium (II) terpyridine complexes: Prospective anti-inflammatory properties in 2021.0, Cited 71.0. Category: indole-building-block. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.
The synthesis and characterization of Ru (II) terpyridine complexes derived from 4 ‘ functionalized 2,2 ‘:6 ‘,2 ”-terpyridine (tpy) ligands are reported. The heteroleptic complexes comprise the synthesized ligands 4 ‘-(2-thienyl)- 2,2 ‘:6 ‘,2 ”-terpyridine) or (4 ‘-(3,4-dimethoxyphenyl)-2,2 ‘:6 ‘,2 ”-terpyridine and (dimethyl 5-(pyrimidin-5-yl)isophthalate). The new complexes [Ru(4 ‘-(2-thienyl)-2,2 ‘:6 ‘,2 ”-terpyridine)(5-(pyrimidin-5-yl)-isophthalic acid)Cl-2] (9), [Ru(4 ‘-(3,4-dimethoxyphenyl)-2,2 ‘:6 ‘,2 ”-terpyridine)(5-(pyrimidin-5-yl)-isophthalic acid)Cl-2] (10), and [Ru(4 ‘-(2-thienyl)-2,2 ‘:6 ‘,2 ”-terpyridine)(5-(pyrimidin-5-yl)-isophthalic acid)(NCS)(2)] (11) were characterized by(1)H- and(13)C-NMR spectroscopy, C, H, N, and S elemental analysis, UPLC-ESI-MS, TGA, FT-IR, and UV-Vis spectroscopy. The biological activities of the synthesized ligands and their Ru (II) complexes as anti-inflammatory, antimicrobial, and anticancer agents were evaluated. Furthermore, the toxicity of the synthesized compounds was studied and compared with the standard drugs, namely, diclofenac potassium and ibuprofen, using hemolysis assay. The results indicated that the ligands and the complex9possess superior anti-inflammatory activities inhibiting albumin denaturation (89.88-100%) compared with the standard drugs (51.5-88.37%) at a concentration of 500 mu g g(-1). These activities were related to the presence of the chelating N-atoms in the ligands and the exchangeable chloro- groups in the complex. Moreover, the chloro- and thiophene groups in complex9produce a higher anticancer activity compared with its isothiocyanate derivative in the complex11and the 3,4-dimethoxyphenyl moiety in complex10. Considering the toxicity results, the synthesized ligands are nontoxic or far less toxic compared with the standard drugs and the metal complexes. Therefore, these newly synthesized compounds are promising anti-inflammatory agents in addition to their moderate unique broad antimicrobial activity.
About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Elnagar, MM; Samir, S; Shaker, YM; Abdel-Shafi, AA; Sharmoukh, W; Abdel-Aziz, MS; Abou-El-Sherbini, KS or concate me.. Category: indole-building-block
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles