An article Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A(1) and its desmethyl derivative bearing F-19-labeling WOS:000462028800021 published article about SOLID-STATE NMR; HYDROGEN-BOND; V-TYPE; P-TYPE; ABSORPTION; PERMEABILITY; INHIBITORS; CONFORMATION; LOCATION; ATPASES in [Hayashi, Tatsuru; Tsuchikawa, Hiroshi; Umegawa, Yuichi; Murata, Michio] Osaka Univ, Grad Sch Sci, 1-1 Machikaneyama, Toyonaka, Osaka 5600043, Japan in 2019.0, Cited 47.0. Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Molecular behavior under bilayer membrane environments is one of the important research topics concerning how organic molecules exert their biological activities when interacting with cellular membranes. However, chemistry-based approaches to this property have not been successful when compared with the structural biological strategy on ligand-receptor interactions. Here, we investigated the molecular behavior of the lipophilic ATPase inhibitor bafilomycin A(1) and its derivatives under a lipid environment from a chemical point of view. Our results revealed significant differences in membrane affinity and dynamics among ligands having different inhibitory potencies, suggesting the specific contribution of ligand-membrane interactions to their biological activity.
Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Hayashi, T; Tsuchikawa, H; Umegawa, Y; Murata, M or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles