Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Connon, Robert, once mentioned the application of 1191951-57-1, Name is PHT-427, molecular formula is C20H31N3O2S2, molecular weight is 409.609, MDL number is MFCD18384970, category is indole-building-block. Now introduce a scientific discovery about this category, Safety of PHT-427.
Herein, we report a base-promoted Zn(II)-bis(oxazoline)-catalyzed one-pot Friedel-Crafts alkylation/Michael addition of 3-(indol-4-yl)acrylonitrile derivatives with trans-beta-nitrostyrenes to yield the tricyclic core of the ergoline skeleton in up to 71% yield and 85% ee. During the purification of 3-(indol-4-yl)acrylonitrile, the key substrate for catalytic studies, a novel trans-cis-trans-cyclobutane derivative, thought to be formed via a [2+2] light-promoted cycloaddition, was identified by X-ray crystallographic analysis. Finally, a novel class of 4-substituted bis(indole)methane derivatives were serendipitously prepared in excellent yield by reacting 4-substituted indole derivatives with 4-nitrobenzaldehyde. One bis(indole)methane was characterized by X-ray crystallographic analysis.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles