Sedano, C; Velasco, R; Feberero, C; Suarez-Pantiga, S; Sanz, R in [Sedano, Carlos; Velasco, Rocio; Feberero, Claudia; Suarez-Pantiga, Samuel; Sanz, Roberto] Univ Burgos, Fac Ciencias, Dept Quim, Area Quim Organ, Burgos 09001, Spain published alpha-Lithiobenzyloxy as a Directed Metalation Group in ortho-Lithiation Reactions in 2020.0, Cited 55.0. COA of Formula: C7H8O2. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.
The alpha-lithiobenzyloxy group, easily generated from aryl benzyl ethers by selective alpha-lithiation with t-BuLi at low temperature, behaves as a directed metalation group (DMG) providing a direct access to o-lithiophenyl alpha-lithiobenzyl ethers. This ortho-directing effect is reinforced in substrates bearing an additional methoxy group at the meta position. The generated dianions can be reacted with a selection of electrophiles including carboxylic esters and dihalosilanes or germanes, which afford interesting benzofuran, sila(germa)dihydrobenzofuran, and silachroman derivatives from simple aryl benzyl ethers.
COA of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Sedano, C; Velasco, R; Feberero, C; Suarez-Pantiga, S; Sanz, R or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles