In an article, author is Jiang, Feng, once mentioned the application of 27538-09-6, Name is 5-Ethyl-4-hydroxy-2-methylfuran-3(2H)-one, molecular formula is C7H10O3, molecular weight is 142.15, MDL number is MFCD03411593, category is indole-building-block. Now introduce a scientific discovery about this category, Name: 5-Ethyl-4-hydroxy-2-methylfuran-3(2H)-one.
Pyrido[1,2-a]-1H-indoles are important scaffolds found in many biologically active compounds. Herein, we first developed an IPrAuCl/AgSbF6-catalyzed cycloisomerization of N-1,3-disubstituted allenyl indoles affording pyrido[1,2-a]-1H-indoles. Then the axial-to-central chirality transfer starting from enantio-enriched N-1,3-disubstituted allenylindoles affording optically active pyrido[1,2-a]-1H-indoles has been realized in excellent yields and enantioselectivities. A mechanism has been proposed based on mechanistic studies. Synthetic applications have also been demonstrated.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles