Recently I am researching about PHOSPHORYLATION CASCADE; HYPERTENSION; COTRANSPORTER; MUTATIONS, Saw an article supported by the JSPS Core-to-Core Program, A. Advanced Research Networks; Japan Agency for Medical Research and Development (AMED)Japan Agency for Medical Research and Development (AMED) [JP20am0101098]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Recommanded Product: 3-(Trifluoromethyl)phenol
We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/ SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 20l is a promising candidate for a new class of antihypertensive drugs.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles