Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 4759-48-2, Name is Isotretinoin, molecular formula is C20H28O2. In an article, author is Raynaud, Clement,once mentioned of 4759-48-2, Formula: https://www.ambeed.com/products/4759-48-2.html.
New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus. Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the beta-lactams against M. abscessus. In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles