An article Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations WOS:000461537000016 published article about ACUTE MYELOID-LEUKEMIA; COVALENT DOCKING; PROTEIN-KINASES; BINDING; FLT3; POTENT; DISCOVERY; RHODESAIN; APPROVAL; DESIGN in [Bensinger, Dennis; Stubba, Daniel; Kohl, Vanessa; Wassmer, Theresa; Stuckert, Johanna; Engemann, Victoria; Schmitz, Katja; Schmidt, Boris] Tech Univ Darmstadt, Clemens Schopf Inst Organ Chem & Biochem, D-64287 Darmstadt, Germany; [Cremer, Anjali; Stegmaier, Kimberly] Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA in 2019.0, Cited 42.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. HPLC of Formula: C7H8O
The use of covalent irreversible binding inhibitors is an established concept for drug development. Usually, the discovery of new irreversible kinase inhibitors occurs serendipitously, showing that efficient rational approaches for the rapid discovery of new drugs are needed. Herein, we report a virtual screening strategy that led to the discovery of irreversible inhibitors of FMS-like tyrosine kinase 3 (FLT3) involved in the pathogenesis of acute myeloid leukemia. A virtual screening library was designed to target the highly conserved Cys828 residue preceding the DFG motif by modification of reported reversible inhibitors with chemically reactive groups. Prospective covalent docking allowed the identification of two lead series, resulting in a massive increase in inhibition of kinase activity and cell viability by irreversible inhibitors compared to the corresponding reversible scaffolds. Lead compound 4b (BSc5371) displays superior cytotoxicity in FLT3-dependent cell lines to compounds in recent clinical trials and overcomes drug-resistant mutations.
HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Bensinger, D; Stubba, D; Cremer, A; Kohl, V; Wassmer, T; Stuckert, J; Engemann, V; Stegmaier, K; Schmitz, K; Schmidt, B or concate me.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles