Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Bellezza, Delia, once mentioned the application of 7554-65-6, Name is 4-Methyl-1H-pyrazole, molecular formula is C4H6N2, molecular weight is 82.1038, MDL number is MFCD00005245, category is indole-building-block. Now introduce a scientific discovery about this category, SDS of cas: 7554-65-6.
The C-C ring closure of alpha-chloromethyl alkyl or aryl N-aryl imines catalyzed with 1 to 10 % Pd(OAc)(2)/P(p-tolyl)(3) afford efficiently 2-aryl- and 2-alkyl-1H-indoles. The heterocyclization reaction involves the initial formation of [2-(arylimino)ethyl]palladium(II) chloride complexes with subsequent C-H activation of the aromatic amine ring. Readily or commercially available alpha-chloromethyl-aryl or -alkyl ketones are used as the precursors. Functionalized indoles at the benzene ring are obtained when the imines are derived from substituted anilines.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles