Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Asymmetric Construction of Quaternary Carbon Centers by Regio- and Enantiocontrolled Allylzincation, Author is Nakamura, Masaharu; Inoue, Toshihiro; Sato, Akihito; Nakamura, Eiichi, which mentions a compound: 132098-59-0, SMILESS is C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1, Molecular C19H18N2O2, Category: indole-building-block.
An allylic zinc reagent bearing a chiral bisoxazoline ligand adds to a substituted cyclopropenone acetal to produce an optically active cyclopropanone acetal possessing a quaternary chiral center in high yield with 97.8-99.8% ee. For example, the allylzincation of 1-ethyl-6,6-dimethyl-4,8-dioxaspiro[2.5]oct-1-ene in the presence of a complex formed from (4S,4’S)-2,2′-methylenebis[4,5-dihydro-4-phenyloxazole] and bromo(2-propenyl)zinc gave (1R)-1-ethyl-6,6-dimethyl-1-(2-propenyl)-4,8-dioxaspiro[2.5]octane in high enantiomeric excess. The steric effects of the bulky bisoxazoline ligand overwhelm the regioselectivity inherent to the electronic property of the olefinic acceptor. High pressure exerts favorable effects on the reaction rate without affecting the high enantioselectivity or regioselectivity.
As far as I know, this compound(132098-59-0)Category: indole-building-block can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles