SDS of cas: 99-93-4. Authors Haldys, K; Goldeman, W; Anger-Gora, N; Rossowska, J; Latajka, R in MDPI published article about in [Haldys, Katarzyna; Latajka, Rafal] Wroclaw Univ Sci & Technol, Dept Bioorgan Chem, PL-50370 Wroclaw, Poland; [Goldeman, Waldemar] Wroclaw Univ Sci & Technol, Dept Organ & Med Chem, PL-50370 Wroclaw, Poland; [Anger-Gora, Natalia; Rossowska, Joanna] Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland in 2021.0, Cited 58.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
A set of 12 monosubstituted acetophenone thiosemicarbazone derivatives (TSCs) were synthesized and their inhibitory properties toward tyrosinase activity were tested. Moreover, their ability to inhibit melanogenesis in the B16F10 murine melanoma cell line was studied. In order to investigate the nature of interactions between the enzyme and the inhibitors, molecular docking to the active site was performed. TSCs 5, 6, 8, and 9 revealed a half maximal inhibitory concentration (IC50) below 1 mu M. Compound 6 turned out to be the most potent tyrosinase inhibitor. All investigated compounds showed reversible inhibition of competitive or mixed type. The para-substituted TSCs had higher affinity for the enzyme as compared to their ortho- and meta-analogues. All investigated compounds inhibited melanin production in B16F10 cells at the micromolar level. Molecular docking showed that the sulfur atom of the thiourea moiety penetrates the active site and interacts with copper ions. The above outcomes might be helpful in the design of new tyrosinase inhibitors in the food and cosmetic industries.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Haldys, K; Goldeman, W; Anger-Gora, N; Rossowska, J; Latajka, R or concate me.. SDS of cas: 99-93-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles