An article Synthesis of 2-Fluoroacetoacetic Acid and 4-Fluoro-3-hydroxybutyric Acid WOS:000469039300013 published article about ORGANIC FLUORINE-COMPOUNDS; CYCLIC SULFATES; BREAST-CANCER; ESTERS; DECARBOXYLATION; ESTERIFICATION; RESOLUTION; CARNITINE in [Mattingly, Stephanie J.; Wuest, Frank] Univ Alberta, Dept Oncol, Cross Canc Inst, 11560 Univ Ave, Edmonton, AB T6G 1Z2, Canada; [Mattingly, Stephanie J.; Schirrmacher, Ralf] Univ Alberta, Dept Oncol, Med Isotope Cyclotron Facil, 6820 116th St, Edmonton, AB T6H 2V8, Canada; [Wuest, Frank; Schirrmacher, Ralf] Univ Alberta, Fac Pharm & Pharmaceut Sci, 2-35 Med Sci Bldg,8613 114th St, Edmonton, AB T6G 2H7, Canada; [Schirrmacher, Ralf] Univ Alberta, Dept Chem, 11227 Saskatchewan Dr, Edmonton, AB T6G 2N4, Canada in 2019.0, Cited 57.0. Category: indole-building-block. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
The butyric acid scaffold is the base structure of several human metabolites that serve diverse and prominent biochemical roles including as oxidative sources of cellular energy and as substrates for biosynthesis. Derivatization of metabolites through incorporation of fluorine often alters bioactivity and can facilitate detection and analysis by nuclear magnetic resonance or positron emission tomography depending upon the fluorine isotope employed. We describe the synthesis of two new fluorinated butyric acids (and three related esters) that are derivatives of the metabolites acetoacetic acid and 3-hydroxybutyric acid. 4-Fluoro-3-hydroxybutyric acid is prepared from epoxy ester precursors via ring opening by triethylamine trihydrofluoride. 2-Fluoroacetoacetic acid is prepared by electrophilic fluorination of an acid-labile -keto ester. The gradual pH-dependent decarboxylation of 2-fluoroacetoacetic acid is investigated by (19) F NMR spectroscopy.
Category: indole-building-block. Welcome to talk about 100-51-6, If you have any questions, you can contact Mattingly, SJ; Wuest, F; Schirrmacher, R or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles