An article Newmultitargetdirectedbenzimidazole-2-thiol-basedheterocycles as prospectiveanti-radicalandanti-Alzheimer’s agents WOS:000566827500001 published article about 2-MERCAPTO BENZIMIDAZOLE; INHIBITORS; DOCKING in [Latif, Abdul; Bibi, Samina; Ali, Sardar; Ammara, Ammara; Ahmad, Manzoor; Ali, Mumtaz] Univ Malakand, Dept Chem, Chakdara, Khyber Pakhtunk, Pakistan; [Khan, Ajmal; Al-Harrasi, Ahmed] Univ Nizwa, UoN Chair Omans Med Plants & Marine Nat Prod, Nizwa, Oman; [Ullah, Farhat] Univ Malakand, Dept Pharm, Chakdara, Khyber Pakhtunk, Pakistan in 2021, Cited 19. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9
A series of new heterocycles (4-18) was synthesized by the structural modification of benzimidazole-2-thiol (BT, 2-MBI). The structures of the synthesized compounds were confirmed with the help of high-resolution mass spectrometry (HRMS) and(1)HNMR spectroscopy. High inhibitions of the oxidants such as ABTS and DPPH were observed for compounds9[IC50(s) = 167.4 mu M (ABTS), 139.5 mu M (DPPH)],10[IC50(s) = 186.5 mu M (ABTS), 155.4 mu M (DPPH)],11[IC50(s) = 286.1 mu M (ABTS), 189.1 mu M (DPPH)],12[IC50(s) = 310.8 mu M (ABTS), 162.2 mu M (DPPH)],14[IC50(s) = 281.3 mu M (ABTS), 205.7 mu M (DPPH)],15[IC50(s) = 284.1 mu M (ABTS), 177.3 mu M (DPPH)], and16[IC50(s) = 344.7 mu M (ABTS), 270.2 mu M (DPPH)] as compared with Ascorbic acid [IC50(s) = 340.9 mu M (ABTS), 164.3 mu M (DPPH)]. The anti-Alzheimer’s activity was performed in vitro against cholinesterase enzymes (AChE, BChE). Compound11was able to show significant inhibitions [IC50(s) = 121.2 mu M (AChE), 38.3 mu M (BChE)] as against that of galantamine [IC50(s) = 139.4 mu M (AChE), 40.3 mu M (BChE)]. Compound14was found as a very good inhibitor of butyrylcholinesterase (IC50= 35.4 mu M) as compared with standard galantamine. Molecular docking was further performed to investigate the mechanism of anticholinesterase activity.
Product Details of 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Latif, A; Bibi, S; Ali, S; Ammara, A; Ahmad, M; Khan, A; Al-Harrasi, A; Ullah, F; Ali, M or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles