What unique challenges do researchers face in 29046-78-4

As far as I know, this compound(29046-78-4)Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kariofillis, Stavros K.; Shields, Benjamin J.; Tekle-Smith, Makeda A.; Zacuto, Michael J.; Doyle, Abigail G. researched the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ).Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex.They published the article 《Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source》 about this compound( cas:29046-78-4 ) in Journal of the American Chemical Society. Keywords: methyl heteroaryl aryl compound preparation DFT; heteroaryl aryl chloride trimethyl orthoformate methylation nickel photoredox catalyst. We’ll tell you more about this compound (cas:29046-78-4).

A radical approach for the methylation of (hetero)aryl chlorides R-Cl (R = 4-CNC6H4, 2-CF3C6H4, 9-oxo-thioxanthen-2-yl, 4-(6-methylpyridin-2-yl)phenyl, 4-phenythiazol-2-yl, etc.) using nickel/photoredox catalysis wherein tri-Me orthoformate, a common laboratory solvent, serves as a Me source has been described. This method permits methylation of (hetero)aryl chlorides and acyl chlorides R1C(O)Cl (R1 = (CH2)10-CH3, adamantan-1-yl, C6H5O, N,N-diphenylamino, etc.) at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that tri-Me orthoformate serves as a source of Me radical via β-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.

As far as I know, this compound(29046-78-4)Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles