Kasper, MA; Glanz, M; Oder, A; Schmieder, P; von Kries, JP; Hackenberger, CPR in [Kasper, Marc-Andre; Glanz, Maria; Oder, Andreas; Schmieder, Peter; von Kries, Jens P.; Hackenberger, Christian P. R.] Leibniz Forschungsinst Mol Pharmakol FMP, Chem Biol Dept, Robert Rossle Str 10, D-13125 Berlin, Germany; [Kasper, Marc-Andre; Glanz, Maria; Hackenberger, Christian P. R.] Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany published Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization in 2019.0, Cited 50.0. Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
In this paper, we introduce vinylphosphonites for chemoselective Staudinger-phosphonite reactions (SPhR) with azides to form vinylphosphonamidates for the subsequent modification of cysteine residues in peptides and proteins. An electron-rich alkene is turned into an electron-deficient vinylphosphonamidate, thereby inducing electrophilic reactivity for a following thiol addition. We show that by varying the phosphonamidate ester substituent we can fine-tune the reactivity of the thiol addition and even control the functional properties of the final conjugate. Furthermore, we observed a drastic increase in thiol addition efficiency when the SPhR is carried out in the presence of a thiol substrate in a one-pot reaction. Hence, we utilize vinylphosphonites for the chemoselective intramolecular cyclization of peptides carrying an azide-containing amino acid and a cysteine in high yields. Our concept was demonstrated for the stapling of a cell-permeable peptidic inhibitor for protein-protein interaction (PPI) between BCL9 and beta-catenin, which is known to create a transcription factor complex playing a role in embryonic development and cancer origin, and for macrocyclization of cell-penetrating peptides (CPPs) to enhance the cellular uptake of proteins.
Formula: C7H8O. Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles