Computed Properties of C8H8O2. In 2020 J IRAN CHEM SOC published article about BIOLOGICAL EVALUATION; SCHIFF-BASE; DNA-BINDING; METAL-COMPLEXES; ANTIBACTERIAL; AGENTS; IDENTIFICATION; NANOCOMPOSITE; PYRIMIDINES; ANALOGS in [Arshad, Mohammad] Shaqra Univ, Dept Basic Sci, Coll Med, Al Dawadmi, Saudi Arabia in 2020, Cited 67. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
An adequate enhancement in the development of resistance by microbial pathogens against the available chemotherapeutic agents prompted us to find out some new chemotherapeutic agents with significant therapeutic effect as antimicrobials. The present study reported the designing of 6-(1H-indol-3-yl)-4,5 ‘-bipyrimidine-2-amine (2) and its Schiff’s bases (3-12), and the computational studies were performed to assess properties (drug likeness and physicochemical). The computationally bioactive compounds (1-12) were then followed for synthesis, characterization, antimicrobial therapeutic effect and percent viability of cells. The antimicrobial therapeutic effect was obtained by disk diffusion method, in terms of zone of inhibition and minimum inhibitory concentration against the gram-positive and gram-negative bacteria [S. aureus (ATCC-25923), S. epidermidis (ATCC-29887)], [E. coli (ATCC-25922), P. mirabilis (ATCC-25933)]. The antimicrobial screening findings reveled that all the compounds (1-12) possessed very good activity and strongly recommended the computational results. The antibiotic ciprofloxacin and the solvent DMSO were used as positive and negative control in the study. The percent viability of the cells was observed using HepG2 cells by MTT assay and noticed that the percent viability of the cells was found in the range 93-97% at lowest concentration 3.125 mu M while 73-77% at the highest 100 mu M. All the compounds (1-12) and ciprofloxacin were then applied for molecular docking assessment to estimate the H-bonding with the residues of GlcN-6-P-synthase, and the findings revealed that significant H-bonding was observed with the binding affinity in the range of – 8.4 to 6.7 kcal/mol and – 7.6 to 6.0 kcal/mol, respectively. Graphic abstract
About 4-Methoxybenzaldehyde, If you have any questions, you can contact Arshad, M or concate me.. Computed Properties of C8H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles