Recently I am researching about NAIL PSORIASIS; NATURALIS OINTMENT; OBSERVER-BLIND; EFFICACY; EXTRACT; SAFETY, Saw an article supported by the Chinese Medicine Research Center, China Medical University from The Featured Areas Research Center Program [CMRC-CHM-2]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Lee, CL; Wang, CM; Hu, HC; Yen, HR; Song, YC; Yu, SJ; Chen, CJ; Li, WC; Wu, YC. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. COA of Formula: C8H8O2
Qing Dai (Naturalis Indigo) is a traditional Chinese medicine (TCM) used as a topical agent in moderate psoriasis, targeting interleukin-17 (IL-17). In this study, it was prepared from the aerial parts of Strobilanthes cusia. Three undescribed indole alkaloid derivatives, indigodoles A-C, along with seven known compounds were isolated from this preparation of Qing Dai and their structures were elucidated from spectroscopic data, including NMR, MS, UV, IR, optical rotation, and CD. As well, most compounds were tested against IL-17. Indigodole C and tryptanthrin could significantly inhibit IL-17 production of Th17 cells. In addition, indigodole A and indirubin showed notably anti-IL-17 gene expression in dose-dependent effects without cytotoxicities toward Th17 and Jurkat cells, respectively. Overall, our studies indicate that the aforementioned indole alkaloids could contribute to anti-IL 17 properties of Qing Dai.
COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Lee, CL; Wang, CM; Hu, HC; Yen, HR; Song, YC; Yu, SJ; Chen, CJ; Li, WC; Wu, YC or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles