Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 110-52-1, is researched, Molecular C4H8Br2, about Synthesis and dopamine receptor binding of dihydrexidine and SKF 38393 catecholamine-based analogues, the main research direction is dihydrexidine SKF catecholamine analog dopamine receptor binding; D1R agonists; D2R and DAT; Dihydrexidine; Dopamine analogs; SKF 38393.Application of 110-52-1.
Dopamine is an important neurotransmitter that regulates numerous essential functions, including cognition and voluntary movement. As such, it serves as an important scaffold for synthesis of novel analogs as part of drug development effort to obtain drugs for treatment of neurodegenerative diseases, such as Parkinson′s disease. To that end, similarity search of the ZINC database based on two known dopamine-1 receptor (D1R) agonists, dihydrexidine (DHX) and SKF 38393, resp., was used to predict novel chem. entities with potential binding to D1R. Three compounds that showed the highest similarity index were selected for synthesis and bioactivity profiling. All main synthesis products as well as the isolated intermediates, were properly characterized. The physico-chem. analyses were performed using HRESIMS, GC/MS, LC/MS with UV-Vis detection, and FTIR, 1H NMR and 13C NMR spectroscopy. Binding to D1 and D2 receptors and inhibition of dopamine reuptake via dopamine transporter were measured for the synthesized analogs of DHX and SKF 38393.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
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