So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cheng, Ran; Sang, Yueqian; Gao, Xing; Zhang, Shu; Xue, Xiao-Song; Zhang, Xingang researched the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ).Name: Nickel(II) chloride ethylene glycol dimethyl ether complex.They published the article 《Highly γ-Selective Arylation and Carbonylative Arylation of 3-Bromo-3,3-difluoropropene via Nickel Catalysis》 about this compound( cas:29046-78-4 ) in Angewandte Chemie, International Edition. Keywords: regioselective arylation carbonylation bromodifluoropropene nickel catalysis; 3-bromo-3,3-difluoropropene; arylboronic acids; carbonylation; gem-difluoroalkenes; nickel catalysis. We’ll tell you more about this compound (cas:29046-78-4).
A nickel-catalyzed highly γ-regioselective arylation and carbonylative arylation of 3-bromo-3,3-difluoropropene has been developed. The reaction proceeds under mild reaction conditions, providing the gem-difluoroalkenes with high efficiency and good functional group tolerance. The resulting gem-difluoroalkenes can serve as versatile building blocks for diversified synthesis. Preliminary mechanistic studies and d. functional theory calculations reveal that both non-radical and radical pathways are possible for the reaction, and the radical pathway is more likely. The high γ-regioselectivity results from the β-bromide elimination of alkylnickel(II) species or from the reductive elimination of nickel(III) species [(aryl)(CF2=CHCH2)NiIII(Ln)X]. The γ-selective carbonylation of 3-bromo-3,3-difluoropropene under 1 atm CO gas also provides a new way for nickel-catalyzed carbonylation. Thus, e.g., (4-tert-butylphenyl)boronic acid + 3-bromo-3,3-difluoropropene → I (86%, 84% isolated) in presence of NiCl2.DME and bpy.
From this literature《Highly γ-Selective Arylation and Carbonylative Arylation of 3-Bromo-3,3-difluoropropene via Nickel Catalysis》,we know some information about this compound(29046-78-4)Name: Nickel(II) chloride ethylene glycol dimethyl ether complex, but this is not all information, there are many literatures related to this compound(29046-78-4).
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles